S18-04 Synchronization of oscillating cells during embryogenesis

S18-04 Synchronization of oscillating cells during embryogenesis

The ability to maintain a proportionate body plan in individuals of different sizes is essential for proper development. Despite wide interest, little is known about the mechanisms underlying scaling with size. I will discuss our efforts to reveal the molecular basis for scaling in different systems. A general ‘‘Expansion– Repression’’ feedback topology will be presented, which ensures scaling ...

Synchronization of Coupled Anizochronous Auto-Oscillating Systems

The particular properties of synchronization are discussed for coupled auto-oscillating systems, which are characterized by non-quadratic law of potential dependence on the coordinate. In particular, structure of the parameter plane (frequency mismatch – coupling value) is considered for coupled van der Pol – Duffing oscillators. The arrangement of synchronization tongues and the particular pro...

I-44: Mutagenesis during Embryogenesis

We developed several novel tools to genome wide screen for CNVs and SNPs in single cells. When applied to cleavage stage embryos from young fertile couples we discovered, unexpectedly, an extremely high incidence of chromosomal instability, a hallmark of tumorigenesis (Vanneste et al., Nature Medicine, 2009; Vanneste et al., Hum.Reprod., 2011). Not only mosaicisms for whole chromosome aneuploid...

Phase Tuning in Synchronization of Nonlinear Master-slave Oscillating Systems Using Decomposition Method

S18-01 Scaling of morphogen gradients during embryonic development

The ability to maintain a proportionate body plan in individuals of different sizes is essential for proper development. Despite wide interest, little is known about the mechanisms underlying scaling with size. I will discuss our efforts to reveal the molecular basis for scaling in different systems. A general ‘‘Expansion– Repression’’ feedback topology will be presented, which ensures scaling ...